Topological properties of gene regulatory networks with qualitatively different gene expression dynamics in spatially organised systems
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چکیده
FACULTY OF SCIENCES SCHOOL OF COMPUTING SCIENCES Doctor of Philosophy by Konstantinos Bougioukos In biological systems, gene expression takes place when genes generate gene products and gene expression levels correspond to concentration levels of these products. Gene expression levels within a single cell are determined by a network of regulatory interactions among genes mediated by gene products. In spatially extended systems consisting of multiple cells gene expression levels within a cell are also affected by gene activity taking place in neighbouring cells. The interplay between spatial interactions among neighbouring cells and the gene regulatory network (GRN) within each cell may qualitatively alter the gene expression dynamics and affects spatially extended essential biological processes such as cell differentiation, pattern formation and morphogenesis. This thesis dealt with: 1. Computational modelling of the interplay between GRN and cell spatial interactions and simulating the spatially organised gene expression dynamics. 2. Reproduce phenomena of gene expression heterogeneity in a spatially extended system and not in a null model and scoring GRNs according to their capacity to organise these phenomena. 3. Investigate associations between network topological properties of GRNs and the capacity of networks to organise gene expression heterogeneity in spatially extended systems.
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تاریخ انتشار 2010